Invention Grant
US08288383B2 3-methyl-2- ( (2S) -2- (4- (3-methyl-L, 2, 4-oxadiazol-5-YL) phenyl) morpholino) -6- (pyrim-idin-4-yl) pyrimidin-4 (3H) -one as tau protein kinase inhibitor
有权
（（2S）-2-（4-（3-甲基-1,2,4-恶二唑-5-基）苯基）吗啉代）-6-（嘧啶-4-基）嘧啶 -4（3H） - 酮作为tau蛋白激酶抑制剂
- Patent Title: 3-methyl-2- ( (2S) -2- (4- (3-methyl-L, 2, 4-oxadiazol-5-YL) phenyl) morpholino) -6- (pyrim-idin-4-yl) pyrimidin-4 (3H) -one as tau protein kinase inhibitor
- Patent Title (中): （（2S）-2-（4-（3-甲基-1,2,4-恶二唑-5-基）苯基）吗啉代）-6-（嘧啶-4-基）嘧啶 -4（3H） - 酮作为tau蛋白激酶抑制剂
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Application No.: US12677161Application Date: 2008-09-12
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Publication No.: US08288383B2Publication Date: 2012-10-16
- Inventor: Daiki Sakai , Kazutoshi Watanabe
- Applicant: Daiki Sakai , Kazutoshi Watanabe
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: JP2007-269484 20070914; JP2007-275714 20070925
- International Application: PCT/JP2008/066929 WO 20080912
- International Announcement: WO2009/035159 WO 20090319
- Main IPC: A61K31/535
- IPC: A61K31/535 ; C07D413/14
Abstract:
A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of tau protein kinase 1 such as a neurodegenerative diseases (e.g. Alzheimer disease).
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