Invention Grant
US08288423B2 FXa inhibitors with cyclic amidines as P4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof
有权
具有作为P4亚基的环脒的FXa抑制剂，其制备方法，及其药物组合物及其衍生物
- Patent Title: FXa inhibitors with cyclic amidines as P4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof
- Patent Title (中): 具有作为P4亚基的环脒的FXa抑制剂，其制备方法，及其药物组合物及其衍生物
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Application No.: US12598010Application Date: 2008-05-09
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Publication No.: US08288423B2Publication Date: 2012-10-16
- Inventor: Young Lag Cho , Ho Young Song , Dae Yon Lee , Sung Yoon Baek , Sang Eun Chae , Sang Hui Jo , Yeon Ok Kim , Hyang Sook Lee , Ju Hyun Park , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
- Applicant: Young Lag Cho , Ho Young Song , Dae Yon Lee , Sung Yoon Baek , Sang Eun Chae , Sang Hui Jo , Yeon Ok Kim , Hyang Sook Lee , Ju Hyun Park , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
- Applicant Address: KR Daejeon
- Assignee: Legochem Bioscience Ltd.
- Current Assignee: Legochem Bioscience Ltd.
- Current Assignee Address: KR Daejeon
- Agency: Sughrue Mion, PLLC
- Priority: KR10-2007-0044980 20070509; KR10-2008-0042740 20080508
- International Application: PCT/KR2008/002619 WO 20080509
- International Announcement: WO2008/140220 WO 20081120
- Main IPC: A01N43/64
- IPC: A01N43/64 ; A01N43/76 ; A01N43/50 ; A01N43/02 ; A01N43/06 ; A61K31/41 ; A61K31/42 ; A61K31/415 ; A61K31/38
Abstract:
The present invention relates to novel oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof, and processes for preparing the same, and pharmaceutical compositions comprising the same. The oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof can be usefully employed as an anticoagulant for treating thromboembolism and tumors via inhibition of coagulation factor Xa.
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