Systems and methods are disclosed for computing various determinations at one or more mobile devices and/or central machines. In part, such determinations are computed based on analysis of one or more inputs originating at one or more sensors of one or more devices. Such determinations include determining an in-vehicle role, an in-vehicle location, a handheld state, and a vehicle class. Various transformations, modifications, and outputs can result from such determinations. Also disclosed are systems and methods for restricting operation of a mobile device, including restrictions that impede operation by a driver moreso than operation by a passenger. Also disclosed are systems and methods for orienting a coordinate system of a mobile device.