Filtration systems may comprise a manifold having a fitting and a filter having a fitting. One of the manifold fitting and the filter fitting may comprise a nozzle including a tip portion having a contact surface. The other of the manifold fitting and the filter fitting may comprise a receptacle which receives the nozzle and has a contact surface. The filter may be removably mountable to the manifold with the filter fitting detachably engaging the manifold fitting and the contact surface at the tip portion of the nozzle abutting and sealing against the contact surface of the receptacle to prevent leakage at the end of the nozzle.