发明授权
- 专利标题: CSF-1R inhibitors, compositions, and methods of use
- 专利标题(中): CSF-1R抑制剂,组合物和使用方法
-
申请号: US12451326申请日: 2008-05-20
-
公开(公告)号: US08293769B2公开(公告)日: 2012-10-23
- 发明人: Simon C. Ng , Keith B. Pfister , Martin Sendzik , James Sutton , Allan S. Wagman , Marion Wiesmann
- 申请人: Simon C. Ng , Keith B. Pfister , Martin Sendzik , James Sutton , Allan S. Wagman , Marion Wiesmann
- 申请人地址: CH Basel
- 专利权人: Novartis AG
- 当前专利权人: Novartis AG
- 当前专利权人地址: CH Basel
- 代理商 Michael G. Smith
- 国际申请: PCT/US2008/006475 WO 20080520
- 国际公布: WO2008/144062 WO 20081127
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; A61K31/519 ; A61K31/506 ; A61K31/501 ; A61K31/497 ; A61K31/4745 ; A61K31/4545 ; A61K31/454 ; A61K31/444 ; A61K31/4439 ; C07D495/04 ; C07D487/04 ; C07D417/12 ; C07D417/14 ; C07D413/12 ; C07D413/14
摘要:
Benzoxazole and benzothiazole compounds and their oxides, esters, prodrugs, solvates, and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF 1R.
公开/授权文献
- US20100130490A1 CSF-1R INHIBITORS,COMPOSITIONS, AND METHODS OF USE 公开/授权日:2010-05-27