发明授权
- 专利标题： Diazole derivatives
- 专利标题（中）： 二唑衍生物
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申请号： US12613089申请日： 2009-11-05
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公开(公告)号： US08293916B2公开(公告)日： 2012-10-23
- 发明人: Bernd Buettelmann , Simona Maria Ceccarelli , Georg Jaeschke , Sabine Kolczewski , Richard Hugh Philip Porter , Paul Spurr , Eric Vieira
- 申请人： Bernd Buettelmann , Simona Maria Ceccarelli , Georg Jaeschke , Sabine Kolczewski , Richard Hugh Philip Porter , Paul Spurr , Eric Vieira
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 优先权： WOPCT/EP2004/005881 20040601; EP04021216 20040907
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; C07D401/04 ; C07D401/06 ; C07D401/14
摘要：
The present invention relates to diazole derivatives of the general formula wherein A, E, R1, R2 and R3 are as defined in application and pharmaceutical compositions containing them. The invention also relates to use of such compounds for the treatment of diseases mediated by the metabotropic glutamate receptors (mGluR), such as anxiety, chronic and acute pain, protection against liver damage, urinary incontinence, obesity, Fragile-X and autism, Alzheimer's disease, epilepsy, schizophrenia, ischemia, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia caused by AIDs, and Parkinson's disease.
公开/授权文献
- US20100048569A1 DIAZOLE DERIVATIVES 公开/授权日：2010-02-25
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