Invention Grant
US08299261B2 1-heterocyclylsulfonyl, 3-aminomethyl, 5-(hetero-) aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors
有权
1-杂环基磺酰基，3-氨基甲基，5-（杂）芳基取代的1 H-吡咯衍生物作为酸分泌抑制剂
- Patent Title: 1-heterocyclylsulfonyl, 3-aminomethyl, 5-(hetero-) aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors
- Patent Title (中): 1-杂环基磺酰基，3-氨基甲基，5-（杂）芳基取代的1 H-吡咯衍生物作为酸分泌抑制剂
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Application No.: US13156216Application Date: 2011-06-08
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Publication No.: US08299261B2Publication Date: 2012-10-30
- Inventor: Masahiro Kajino , Atsushi Hasuoka , Haruyuki Nishida
- Applicant: Masahiro Kajino , Atsushi Hasuoka , Haruyuki Nishida
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Edwards Wildman Palmer LLP
- Agent David G. Conlin, Esq.; Elbert Chiang
- Priority: JP2005-250356 20050830; JP2006-100626 20060331
- Main IPC: C07D401/02
- IPC: C07D401/02
Abstract:
The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.
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