Systems, methods, and computer-readable media for adjusting a timer mechanism based on radio frequency (RF) conditions of a network connecting source and destination devices are provided. Initially, data packets transmitted by the source device are assigned an ordering. This ordering is compared to an actual order in which the data packets are received at the destination device to ascertain whether any data packets were missing due to RF conditions. A negative response indicating missing, or lost, data packets may be returned, thereby invoking the source device to retransmit the data packets identified as missing. The device(s) may compute a probability of packet-loss (utilizing a recorded history of the transmitted packets in conjunction with the data packets actually received) and utilize the packet-loss probability to dynamically tune a time-interval of the timer mechanism. Upon expiration of the time-interval, the timer mechanism instructs the source device to retransmit the initial data packets.