In described embodiments, filter parameters for a filter applied to a signal in, for example, a Serializer/De-serializer (SerDes) receiver and/or transmitter are generated based on real-time monitoring of a data eye. The real-time eye monitor monitors data eye characteristics of the signal present in a data path, the data path applying the filter to the signal. The eye monitor generates eye statistics from the monitored data eye characteristics and an adaptive controller generates a set of parameters for the filter of the data path for statistical calibration of the data eye, wherein the eye monitor continuously monitors the data eye and the adaptive controller continuously generates the set of parameters based on the eye statistics.