A paper sheet processing device is provided in which no load is imposed on a primary drive which drives a pressing part for pressing the paper sheets stacked and accommodated and a shutter for opening and closing an insertion slot. The paper sheet processing device of the present invention has an insertion slot through which a paper sheet is inserted, a shutter 8 for opening and closing the insertion slot, a paper magazine in which paper sheets loaded through the insertion slot are sequentially stacked and accommodated, a pressing part 50 which comes into contact with paper sheets accommodated in the paper magazine to press the stacked paper sheets, a cam groove 61A which operates the shutter 8 and the pressing part 50, and a drive motor for driving the cam groove 61A, and the cam groove 61A has such a shape that while one of the shutter 8 and pressing part 50 is in operation, the operation of the other is stopped.