发明授权
- 专利标题： Pyridyl derivatives, their preparation and use
- 专利标题（中）： 吡啶衍生物，其制备和用途
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申请号： US12672485申请日： 2008-08-06
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公开(公告)号： US08314103B2公开(公告)日： 2012-11-20
- 发明人: Sanjay Kumar , Kalpana Sanjay Joshi , Vijaykumar Deore , Mandar Ramesh Bhonde , Nilambari Nilkanth Yewalkar , Amol Arun Padgaonkar , Asha Adrian Kulkarni-Almeida , Maggie Joyce Rathos , Sapna Parikh , Nilesh Madhukar Dagia
- 申请人： Sanjay Kumar , Kalpana Sanjay Joshi , Vijaykumar Deore , Mandar Ramesh Bhonde , Nilambari Nilkanth Yewalkar , Amol Arun Padgaonkar , Asha Adrian Kulkarni-Almeida , Maggie Joyce Rathos , Sapna Parikh , Nilesh Madhukar Dagia
- 申请人地址： IN Mumbai, Maharashtra
- 专利权人： Piramal Enterprises Limited
- 当前专利权人： Piramal Enterprises Limited
- 当前专利权人地址： IN Mumbai, Maharashtra
- 代理机构： Ladas & Parry LLP
- 国际申请： PCT/IB2008/053151 WO 20080806
- 国际公布： WO2009/019656 WO 20090212
- 主分类号： A61K31/50
- IPC分类号： A61K31/50 ; C07D401/00
摘要：
The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3k), mammalian target of rapamycin (mTOR) and/or hypoxia inducible factor 1α (HIF-1α) mediated signaling. Also disclosed are processes for preparation of the pyridyl derivatives, and their use in the manufacture of pharmaceutical compositions for the treatment of clinical conditions caused by deregulation of signaling pathways selected from one or more of PI3K, mTOR and HIF-1α pathways. The pyridyl derivatives are also useful for the treatment of conditions or disorders mediated by TNF-α.
公开/授权文献
- US20110077252A1 PYRIDYL DERIVATIVES, THEIR PREPARATION AND USE 公开/授权日：2011-03-31
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