Invention Grant
- Patent Title: Pyridyl derivatives, their preparation and use
- Patent Title (中): 吡啶衍生物，其制备和用途
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Application No.: US12672485Application Date: 2008-08-06
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Publication No.: US08314103B2Publication Date: 2012-11-20
- Inventor: Sanjay Kumar , Kalpana Sanjay Joshi , Vijaykumar Deore , Mandar Ramesh Bhonde , Nilambari Nilkanth Yewalkar , Amol Arun Padgaonkar , Asha Adrian Kulkarni-Almeida , Maggie Joyce Rathos , Sapna Parikh , Nilesh Madhukar Dagia
- Applicant: Sanjay Kumar , Kalpana Sanjay Joshi , Vijaykumar Deore , Mandar Ramesh Bhonde , Nilambari Nilkanth Yewalkar , Amol Arun Padgaonkar , Asha Adrian Kulkarni-Almeida , Maggie Joyce Rathos , Sapna Parikh , Nilesh Madhukar Dagia
- Applicant Address: IN Mumbai, Maharashtra
- Assignee: Piramal Enterprises Limited
- Current Assignee: Piramal Enterprises Limited
- Current Assignee Address: IN Mumbai, Maharashtra
- Agency: Ladas & Parry LLP
- International Application: PCT/IB2008/053151 WO 20080806
- International Announcement: WO2009/019656 WO 20090212
- Main IPC: A61K31/50
- IPC: A61K31/50 ; C07D401/00
Abstract:
The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3k), mammalian target of rapamycin (mTOR) and/or hypoxia inducible factor 1α (HIF-1α) mediated signaling. Also disclosed are processes for preparation of the pyridyl derivatives, and their use in the manufacture of pharmaceutical compositions for the treatment of clinical conditions caused by deregulation of signaling pathways selected from one or more of PI3K, mTOR and HIF-1α pathways. The pyridyl derivatives are also useful for the treatment of conditions or disorders mediated by TNF-α.
Public/Granted literature
- US20110077252A1 PYRIDYL DERIVATIVES, THEIR PREPARATION AND USE Public/Granted day:2011-03-31
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