发明授权
US08314233B2 Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters
有权
制备2-(氨基亚甲基)-4,4-二氟-3-氧代丁酸酯的方法
- 专利标题: Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters
- 专利标题(中): 制备2-(氨基亚甲基)-4,4-二氟-3-氧代丁酸酯的方法
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申请号: US12990359申请日: 2009-04-30
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公开(公告)号: US08314233B2公开(公告)日: 2012-11-20
- 发明人: Thomas Zierke , Volker Maywald , Michael Rack , Sebastian Peer Smidt , Michael Keil , Bernd Wolf , Christopher Koradin
- 申请人: Thomas Zierke , Volker Maywald , Michael Rack , Sebastian Peer Smidt , Michael Keil , Bernd Wolf , Christopher Koradin
- 申请人地址: DE Ludwigshafen
- 专利权人: BASF SE
- 当前专利权人: BASF SE
- 当前专利权人地址: DE Ludwigshafen
- 代理机构: Brinks Hofer Gilson & Lione
- 优先权: EP08155612 20080502
- 国际申请: PCT/EP2009/055283 WO 20090430
- 国际公布: WO2009/133178 WO 20091105
- 主分类号: C07D295/145
- IPC分类号: C07D295/145 ; C07D211/34 ; C07D265/30
摘要:
The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters, 2-(aminomethylidene)-4,4-difluoro-3-oxobutteric esters of the formula (I) in which R1, R2 and R3 independently of one another are C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C3-C10-cycloalkyl or benzyl or NR2R3 is a 5- to 10-membered heterocyclic radical, to a process for preparing compounds of the formula (I) wherein an appropriate 3-aminoacrylic ester is reacted with difluoroacetyl fluoride and to the use of compounds of the formula (I) in the process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters.
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