发明授权
US08314233B2 Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters 有权
制备2-(氨基亚甲基)-4,4-二氟-3-氧代丁酸酯的方法

Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters
摘要:
The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters, 2-(aminomethylidene)-4,4-difluoro-3-oxobutteric esters of the formula (I) in which R1, R2 and R3 independently of one another are C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C3-C10-cycloalkyl or benzyl or NR2R3 is a 5- to 10-membered heterocyclic radical, to a process for preparing compounds of the formula (I) wherein an appropriate 3-aminoacrylic ester is reacted with difluoroacetyl fluoride and to the use of compounds of the formula (I) in the process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters.
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