An object of the present invention is to provide a method of driving a micromachine and a drive mechanism whereby the required drive force can be obtained and that avoid excessive load to the machine, the mechanism not being of large size and not being troublesome in terms of energy supply. In a micromachine rotary drive mechanism according to the present invention, a micro-turbine is floated on the liquid surface of Fluorinert, silicone oil is attached onto faces respectively directed in the same direction of this micro-turbine, thereby drive force of the micro-turbine is obtained from the surface tension difference convection generated at the two-fluid interface. Also, in a unidirectional drive mechanism of a micromachine according to the present invention, a minute thin sheet is floated on a Fluorinert liquid surface, silicone oil is attached to one end of this minute thin sheet, thereby drive force of this minute thin sheet is obtained from the surface tension difference convection generated at the two-fluid interface.