发明授权
US08318801B2 Cinnamic compounds and derivatives therefrom for the inhibition of histone deacetylase
有权
肉桂酸化合物及其衍生物用于抑制组蛋白脱乙酰酶
- 专利标题： Cinnamic compounds and derivatives therefrom for the inhibition of histone deacetylase
- 专利标题（中）： 肉桂酸化合物及其衍生物用于抑制组蛋白脱乙酰酶
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申请号： US13114619申请日： 2011-05-24
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公开(公告)号： US08318801B2公开(公告)日： 2012-11-27
- 发明人: Chung-Yang Huang , Chia-Nan Chen , Wei-Jan Huang , Chia-Wei Lin , Jing-Shi Huang , Li-Ling Chi , Ai-Ling Chen , Chi-Yun Lee , Yu-Chen Huang
- 申请人： Chung-Yang Huang , Chia-Nan Chen , Wei-Jan Huang , Chia-Wei Lin , Jing-Shi Huang , Li-Ling Chi , Ai-Ling Chen , Chi-Yun Lee , Yu-Chen Huang
- 申请人地址： TW Taipei
- 专利权人： Naturewise Biotech & Medicals Corporation
- 当前专利权人： Naturewise Biotech & Medicals Corporation
- 当前专利权人地址： TW Taipei
- 代理机构： WPAT, P.C.
- 代理商 Anthony King
- 主分类号： A01N43/08
- IPC分类号： A01N43/08 ; A01N37/18 ; A01N37/00 ; A01N37/10
摘要：
The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-cancer, anti-diabetic, and anti-neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Spinocerebellar Ataxias (SCA), and human spinal muscular atrophy (SMA).
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