发明授权
US08318957B2 Semisynthesis process for the preparation of 10 deacetyl-N-debenzoyl-paclitaxel 有权
制备10种脱乙酰-N-去苯甲酰紫杉醇的半合成方法

Semisynthesis process for the preparation of 10 deacetyl-N-debenzoyl-paclitaxel
摘要:
A process for the preparation of 10-deacetyl-bis-7,10-trichloroacetylbaccatin III (VI) said process comprising: reacting 10-deacetylbaccatin III with a trichloroacetic acid activated derivative to obtain a reaction mixture, and performing an isolation step on said reaction mixture obtain purified 10-deacetyl-bis-7,10-trichloroacetylbaccatin III (VI) having a content, of corresponding 7- or 10 mono-trichloroacetyl derivatives lower than 0.1% as determined by HPLC.
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