发明授权
US08318957B2 Semisynthesis process for the preparation of 10 deacetyl-N-debenzoyl-paclitaxel
有权
制备10种脱乙酰-N-去苯甲酰紫杉醇的半合成方法
- 专利标题: Semisynthesis process for the preparation of 10 deacetyl-N-debenzoyl-paclitaxel
- 专利标题(中): 制备10种脱乙酰-N-去苯甲酰紫杉醇的半合成方法
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申请号: US12104715申请日: 2008-04-17
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公开(公告)号: US08318957B2公开(公告)日: 2012-11-27
- 发明人: Bruno Gabetta , Andrea Gambini , Ezio Bombardelli , Gabriele Fontana
- 申请人: Bruno Gabetta , Andrea Gambini , Ezio Bombardelli , Gabriele Fontana
- 申请人地址: IT Milan
- 专利权人: Indena S.p.A.
- 当前专利权人: Indena S.p.A.
- 当前专利权人地址: IT Milan
- 代理机构: Young & Thompson
- 优先权: EP04425752 20041008; EP05007888 20050411
- 主分类号: C07D305/00
- IPC分类号: C07D305/00
摘要:
A process for the preparation of 10-deacetyl-bis-7,10-trichloroacetylbaccatin III (VI) said process comprising: reacting 10-deacetylbaccatin III with a trichloroacetic acid activated derivative to obtain a reaction mixture, and performing an isolation step on said reaction mixture obtain purified 10-deacetyl-bis-7,10-trichloroacetylbaccatin III (VI) having a content, of corresponding 7- or 10 mono-trichloroacetyl derivatives lower than 0.1% as determined by HPLC.
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