In a liquid crystal display (LCD) panel driver with a self-masking function using a power-on reset signal, and in a method of driving the same, the LCD panel driver includes a power-on reset signal generation unit that generates a power-on reset signal in response to a supply voltage applied to a LCD panel; a latch unit that receives a start pulse signal instructing that source lines of the LCD panel be driven and generates first and second set signals for setting an initial value of an output signal of a flip-flop to be in a predetermined default logic level, in response to the power-on reset signal; and a counter unit that generates a start pulse masking signal by masking at least one pulse of the start pulse signal in response to the first and second set signals and the start pulse signal.