The invention provides a method for directing operation of a microphone system. In one embodiment, the microphone system comprises a plurality of component modules. First, a diagnostic test is performed to determine a diagnostic result indicating whether the component modules have failed the diagnostic test. Whether a plurality of required component modules corresponding to a current application mode for operating the microphone system have failed the diagnostic test is then determined according to the diagnostic result, wherein the application mode requires cooperation of the required component modules selected from the component modules of the microphone system. When some of the required component modules have failed the diagnostic test, the current application mode is changed to an altered application mode and the microphone system is directed to operate according to the altered application mode, wherein a plurality of second required component modules corresponding to the altered application mode are in good condition. When the required component modules are all in good condition, the microphone system is directed to operate according to the current application mode.