A system and method for denoising using signal dependent adaptive weights includes an imaging device that captures image data corresponding to a photographic target. A denoising manager identifies similar pixels from said image data that are located within a pre-defined processing window around the pixel to be denoised. The denoising manager computes signal-dependent weighting values that correspond to respective ones of the similar pixels. The denoising manager then calculates the denoised pixel value by utilizing the weighting values in conjunction with raw pixel values of the similar pixel set. In this manner all pixels in the image are denoised.