发明授权
- 专利标题： Humanized antibodies against the β-amyloid peptide
- 专利标题（中）： 针对β-淀粉样蛋白肽的人源化抗体
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申请号： US12677732申请日： 2008-09-15
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公开(公告)号： US08323647B2公开(公告)日： 2012-12-04
- 发明人: Stefan Ewert , Adrian Auf Der Maur , Susann Cattepoel , Roger Nitsch
- 申请人： Stefan Ewert , Adrian Auf Der Maur , Susann Cattepoel , Roger Nitsch
- 申请人地址： CH Schlieren CH Zurich
- 专利权人： Delenex Therapeutics AG,University of Zurich
- 当前专利权人： Delenex Therapeutics AG,University of Zurich
- 当前专利权人地址： CH Schlieren CH Zurich
- 代理机构： Lathrop & Gage LLP
- 代理商 James H. Velema, Esq.
- 国际申请： PCT/CH2008/000382 WO 20080915
- 国际公布： WO2009/033309 WO 20090319
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/18 ; C12P21/08
摘要：
The invention discloses an isolated antibody that selectively binds to the C-terminal part of Abeta and is humanized or fully human. The antibody of the invention is capable of preventing oligomerization of Abeta. Furthermore, a method of diagnosis comprising the steps of: (i) Labelling an antibody; (ii) Administering an effective dose of said antibody intranasally or systemically to a subject; and (iii) Detecting the concentration and/or presence of the labelled antibody in body parts of the subject is disclosed.
公开/授权文献
- US20110020220A1 HUMANIZED ANTIBODIES AGAINST THE BETA-AMYLOID PEPTIDE 公开/授权日：2011-01-27
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