发明授权
US08324249B2 Tetrahydropyridinyl and dihydropyrrolyl compounds and the use thereof
有权
四氢吡啶基和二氢吡咯基化合物及其用途
- 专利标题： Tetrahydropyridinyl and dihydropyrrolyl compounds and the use thereof
- 专利标题（中）： 四氢吡啶基和二氢吡咯基化合物及其用途
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申请号： US13056839申请日： 2009-08-03
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公开(公告)号： US08324249B2公开(公告)日： 2012-12-04
- 发明人: Hidenori Mikamiyama , Chiyou Ni , Bin Shao , Laykea Tafesse
- 申请人： Hidenori Mikamiyama , Chiyou Ni , Bin Shao , Laykea Tafesse
- 申请人地址： US CT Stamford JP Osaka
- 专利权人： Purdue Pharma L.P.,Shionogi & Co., Ltd.
- 当前专利权人： Purdue Pharma L.P.,Shionogi & Co., Ltd.
- 当前专利权人地址： US CT Stamford JP Osaka
- 代理机构： Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 国际申请： PCT/US2009/004437 WO 20090803
- 国际公布： WO2010/014257 WO 20100204
- 主分类号： A01N43/40
- IPC分类号： A01N43/40 ; A61K31/445
摘要：
The invention relates to tetrahydropyridinyl and dihydropyrrolyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X, Y, Z, R1, R2, m, and n are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.