发明授权
US08324265B2 Heterocyclic compounds having type I 11β hydroxysteroid dehydrogenase inhibitory activity
有权
具有I 11和bgr的杂环化合物 羟类固醇脱氢酶抑制活性
- 专利标题: Heterocyclic compounds having type I 11β hydroxysteroid dehydrogenase inhibitory activity
- 专利标题(中): 具有I 11和bgr的杂环化合物 羟类固醇脱氢酶抑制活性
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申请号: US12093903申请日: 2006-11-20
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公开(公告)号: US08324265B2公开(公告)日: 2012-12-04
- 发明人: Noriyuki Kurose , Mikayo Hayashi , Tomoyuki Ogawa , Koji Masuda , Eiichi Kojima
- 申请人: Noriyuki Kurose , Mikayo Hayashi , Tomoyuki Ogawa , Koji Masuda , Eiichi Kojima
- 申请人地址: JP Osaka
- 专利权人: Shionogi & Co., Ltd.
- 当前专利权人: Shionogi & Co., Ltd.
- 当前专利权人地址: JP Osaka
- 代理机构: Hamre, Schumann, Mueller & Larson, P.C.
- 优先权: JP2005-335995 20051121
- 国际申请: PCT/JP2006/323096 WO 20061120
- 国际公布: WO2007/058346 WO 20070524
- 主分类号: A61K31/551
- IPC分类号: A61K31/551 ; A61K31/5377 ; A61K31/506 ; A61K31/496 ; A61K31/454 ; A61K31/4439 ; A61K31/427 ; A61K31/4245 ; A61K31/4178 ; A61K31/4155 ; A61K31/415 ; C07D417/06 ; C07D417/12 ; C07D413/06 ; C07D413/12 ; C07D409/06 ; C07D409/12 ; C07D401/14 ; C07D401/12 ; C07D401/06 ; C07D403/06 ; C07D403/12 ; C07D231/20 ; C07D231/18
摘要:
Disclosed is a compound useful as a type I 11βhydroxysteroid dehydrogenase inhibitor.A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is optionally substituted alkyl or the like, one of R2 and R4 is a group of formula: —Y—R5, wherein Y is —O— or the like, R5 is substituted alkyl (the substituent is optionally substituted cycloalkyl or the like), optionally substituted branched alkyl or the like, the other of R2 and R4 is hydrogen or optionally substituted alkyl, R3 is a group of formula: —C(═O)—Z—R6, wherein Z is —NR7— or —NR7—W—, R6 is optionally substituted cycloalkyl or the like, R7 is hydrogen or optionally substituted alkyl, W is optionally substituted alkylene, X is ═N— or the like, with the proviso that compounds wherein R2 is 2-(morphorino)ethoxy, R3 is N-(1-adamantyl)carbamoyl and R1 is benzyl are excluded.