发明授权
- 专利标题: Chimeric immunoreceptor useful in treating human gliomas
- 专利标题(中): 嵌合免疫受体可用于治疗人神经胶质瘤
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申请号: US13046518申请日: 2011-03-11
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公开(公告)号: US08324353B2公开(公告)日: 2012-12-04
- 发明人: Michael Jensen
- 申请人: Michael Jensen
- 申请人地址: US CA Durate
- 专利权人: City of Hope
- 当前专利权人: City of Hope
- 当前专利权人地址: US CA Durate
- 代理机构: Rothwell, Figg, Ernst & Manbeck, P.C.
- 主分类号: C07K16/46
- IPC分类号: C07K16/46 ; C07K19/00 ; C12N5/0783 ; C12N5/22 ; C12N15/63
摘要:
The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy. In a preferred embodiment is a glioma-specific immunoreceptor comprising the extracellular targeting domain of the IL-13Rα2-specific IL-13 mutant IL-13(E13Y) linked to the Fc region of IgG, the transmembrane domain of human CD4, and the human CD3 zeta chain.
公开/授权文献
- US20110223129A1 CHIMERIC IMMUNORECEPTOR USEFUL IN TREATING HUMAN CANCERS 公开/授权日:2011-09-15