发明授权
US08324366B2 Compositions and methods for delivering RNAI using lipoproteins
有权
使用脂蛋白递送RNAI的组合物和方法
- 专利标题： Compositions and methods for delivering RNAI using lipoproteins
- 专利标题（中）： 使用脂蛋白递送RNAI的组合物和方法
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申请号： US12432192申请日： 2009-04-29
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公开(公告)号： US08324366B2公开(公告)日： 2012-12-04
- 发明人: Akin Akinc , Tomoko Nakayama , Muthiah Manoharan , Markus Stoffel
- 申请人： Akin Akinc , Tomoko Nakayama , Muthiah Manoharan , Markus Stoffel
- 申请人地址： US MA Cambridge CH Zurich
- 专利权人： Alnylam Pharmaceuticals, Inc.,Eth Zurich
- 当前专利权人： Alnylam Pharmaceuticals, Inc.,Eth Zurich
- 当前专利权人地址： US MA Cambridge CH Zurich
- 代理机构： Lando & Anastasi, LLP
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/04
摘要：
This invention relates to new compositions comprising at least one of a single or double stranded oligonucleotide, where said oligonucleotide has been conjugated to a lipophile and to which the conjugated oligonucleotide has been preassembled with lipoproteins. These compositions are effectively in delivering oligonucleotides to mammalian tissue where they effect gene silencing.
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