Methods disclosed permit the enhancement of difference images associated with an image pair. In some embodiments, an enhanced difference image may be generated by selecting at least one non-zero target pixel in a thresholded difference image and performing operations on pixels that neighbor the target pixel in the thresholded difference image based on the value associated with the target pixel. In some embodiments, the operations on neighbors of the target pixel may be carried out using a user-specified paintbrush. The enhanced difference image may be rendered using a monitor or a printer.