发明授权
US08329661B2 Method for using HIP/PAP polypeptide composition for liver regeneration and prevention of liver failure
有权
使用HIP / PAP多肽组合物进行肝脏再生和预防肝功能衰竭的方法
- 专利标题： Method for using HIP/PAP polypeptide composition for liver regeneration and prevention of liver failure
- 专利标题（中）： 使用HIP / PAP多肽组合物进行肝脏再生和预防肝功能衰竭的方法
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申请号： US13032521申请日： 2011-02-22
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公开(公告)号： US08329661B2公开(公告)日： 2012-12-11
- 发明人: Laurence Christa , Christian Brechot , Marie-Thérèse Simon-Gage-Soufflot , Alain Pauloin , J. Guilherme Tralhao
- 申请人： Laurence Christa , Christian Brechot , Marie-Thérèse Simon-Gage-Soufflot , Alain Pauloin , J. Guilherme Tralhao
- 申请人地址： FR Paris FR Paris
- 专利权人： Instiut National de la Santéet de la Recherche Médicale (INSERM),Universite Rene Descartes
- 当前专利权人： Instiut National de la Santéet de la Recherche Médicale (INSERM),Universite Rene Descartes
- 当前专利权人地址： FR Paris FR Paris
- 代理机构： Fulbright & Jaworski L.L.P.
- 优先权： EP03291487 20030618
- 主分类号： A61P1/16
- IPC分类号： A61P1/16 ; A61K38/17 ; C07K14/47
摘要：
This invention is based on the experimental finding that HIP/PAP has mitogenic and antiapoptotic effects in vitro on hepatocytes in primary culture. Moreover, HIP/PAP is a mitogenic and anti-apoptotic molecule for hepatocytcs, in vivo, during liver failure and liver regeneration. The present invention is also based on the experimental finding that HIP/PAP administration has no adverse effects in mammals. This invention concerns a pharmaceutical composition for stimulating liver regeneration in vivo including after chronic/acute liver failure, comprising an effective amount of a polypeptide comprising an amino acid sequence having 90% amino acid identity with the polypeptide consisting of the amino acid sequence starting at the amino acid residue (36) and ending at the amino acid residue (175) of sequence SEQ ID No 1, in combination with at least one physiologically acceptable excipient.
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