发明授权
- 专利标题: Substituted indoles and a method for the production and use thereof
- 专利标题(中): 取代的吲哚及其制备和使用方法
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申请号: US12600251申请日: 2007-05-17
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公开(公告)号: US08329689B2公开(公告)日: 2012-12-11
- 发明人: Andrey Alexandrovich Ivashchenko , Sergey Yevgenievich Tkachenko , Alexander Viktorovich Khvat , Oleg Dmitrievich Mitkin , Ilya Matusovich Okun , Alexandr Sergeevich Kyselvev , Volodymyr Mikhailovich Kysil , Nikolay Filippovich Savchuk , Alexander Vasilievich Ivachtchenko
- 申请人: Andrey Alexandrovich Ivashchenko , Sergey Yevgenievich Tkachenko , Alexander Viktorovich Khvat , Oleg Dmitrievich Mitkin , Ilya Matusovich Okun , Alexandr Sergeevich Kyselvev , Volodymyr Mikhailovich Kysil , Nikolay Filippovich Savchuk , Alexander Vasilievich Ivachtchenko
- 申请人地址: US CA Encinitas RU Moscow US CA Rancho Santa Fe
- 专利权人: Alexandre Vasilievich Ivachtchenko,Andrey Alexandrovich Ivashchenko,Nikolay Filippovich Savchuk
- 当前专利权人: Alexandre Vasilievich Ivachtchenko,Andrey Alexandrovich Ivashchenko,Nikolay Filippovich Savchuk
- 当前专利权人地址: US CA Encinitas RU Moscow US CA Rancho Santa Fe
- 代理机构: Sughrue Mion, PLLC
- 优先权: RU2006-117557 20060523; RU2006-117558 20060523
- 国际申请: PCT/RU2007/000244 WO 20070517
- 国际公布: WO2007/136300 WO 20071129
- 主分类号: A61K31/404
- IPC分类号: A61K31/404 ; A61K31/407 ; C07D209/12 ; C07D498/04
摘要:
The invention relates to novel substituted indoles, to the use thereof in the form of pharmacological composition substances and to use of said composition for producing medicinal preparations used for preventing and treating viral diseases, in particular caused by viruses of infectious hepatitis (HCV, HBV), human immune deficiency (HIV), atypical pneumonia (SARS) and bird flu. The invention proposes novel substituted indoles of general formula (1) or the racemates or the optical isomers or the pharmaceutically acceptable salts and/or hydrates thereof, wherein R1, R14 and R24 independently of each other are an aminogroup substituent selected for hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl, or R14 and R24 together with a nitrogen atom, with which they are bound, form through R14 and R24 optionally substituted azaheterocyclyl or guanidyl; R2 is analkyl substituent selected from hydrogen, an optionally substituted mercaptogroup, optionally substituted aminogroup and optionally substituted hydroxyl; R3 is lower alkyl, R5 is an hydrogen atom or R5 together with an oxygen atom with which it is linked or R24 together with a nitrogen atom with which it is linked close, via R5 and R24 an oxazine cycle; R6 is a cyclic system substituent selected for hydrogen, a halogen atom, cyanogroup, optionally substituted aryl or substituted heterocyclyl.