Invention Grant
US08329938B2 Hydroxyalkanoic acid and hydroxyalkanoice acid oligomer esters of retinol
有权
视黄醇的羟基链烷酸和羟基链烷酸酸低聚物酯
- Patent Title: Hydroxyalkanoic acid and hydroxyalkanoice acid oligomer esters of retinol
- Patent Title (中): 视黄醇的羟基链烷酸和羟基链烷酸酸低聚物酯
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Application No.: US13031375Application Date: 2011-02-21
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Publication No.: US08329938B2Publication Date: 2012-12-11
- Inventor: Neil Warren Boaz
- Applicant: Neil Warren Boaz
- Applicant Address: US TN Kingsport
- Assignee: Eastman Chemical Company
- Current Assignee: Eastman Chemical Company
- Current Assignee Address: US TN Kingsport
- Agent Jennifer R. Knight; Michael K. Carrier
- Main IPC: C07C69/66
- IPC: C07C69/66 ; C07C69/74 ; C07C69/34 ; A61K8/02

Abstract:
Retinyl hydroxyesters and retinyl oligo-hydroxyesters were prepared using a chemoenzymatic process from retinol and short chain esters of hydroxycarboxylic acids or short chain esters of hydroxycarboxylic acids. The presence of the hydroxyl group on the acid can result in a mixture of esters from various oligomers of the hydroxycarboxylic acid. The retinyl ester products are readily enzymatically hydrolyzed in vitro, which indicates that application to the skin should result in release of the anti-aging ingredient retinol (without the inherent instability and irritation) along with the acid, which, if chosen appropriately, should also have desirable biological effects. This combination should be effective as an anti-aging skin care ingredient.
Public/Granted literature
- US20120215024A1 HYDROXYALKANOIC ACID AND HYDROXYALKANOICE ACID OLIGOMER ESTERS OF RETINOL Public/Granted day:2012-08-23
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