A circuit arrangement and method utilize a universal, standardized inter-layer interconnect in a multi-layer semiconductor stack to facilitate interconnection and communication between functional units disposed on a stack of semiconductor dies. Each circuit layer in the multi-layer semiconductor stack is required to include an inter-layer interface region that is disposed at substantially the same topographic location such that when the semiconductor dies upon which such circuit layers are disposed are arranged together in a stack, electrical conductors disposed within each semiconductor die are aligned with one another to provide an inter-layer bus that is oriented vertically, or transversely, with respect to the individual circuit layers. Based upon a standardized placement of the inter-layer interface region in each circuit layer, and a standardized arrangement of electrical conductors associated with the inter-layer bus, each circuit layer may designed using a standardized template upon which the design features necessary to implement the inter-layer bus are already provided, thereby simplifying circuit layer design and the interconnection of functional units to the inter-layer bus. In addition, vertically-oriented supernodes may be defined within a semiconductor stack to provide multiple independently-operating nodes having functional units disposed in multiple circuit layers of the stack.