In a single-carrier frequency division multiple access (SC-FDMA) system, a receiver receives transmission symbols from a transmitter, determines a set of subbands used by the transmitter, processes the received transmission symbols for the set of subbands, obtains received pilot values for a transmitted pilot, and obtains received data values for transmitted data. The receiver may iteratively perform channel and interference estimation for the transmitter. The receiver selects an initial interference estimate, derives a channel estimate based on the received pilot values and the interference estimate, and derives a new interference estimate based on the received pilot values and the channel estimate. The receiver may repeat the derivation of the channel estimate and the interference estimate for multiple iterations. The receiver then performs data detection and/or receiver spatial processing on the received data values based on the channel estimate and the interference estimate.