A method and apparatus of transmitting and receiving data in a mobile communication system is disclosed. The method of transmitting and receiving data in a mobile communication system comprises receiving control information related to transmission and reception from a transmitting side, determining at least one of power saving parameter information of a talk spurt and a silence period from the control information related to transmission and reception, and receiving data from the transmitting side by applying the power saving parameter information depending on the talk spurt and the silence period. According to the above method, unnecessary data reception is not performed in the silence period.