A multi-axial light guide module comprises a light guide, a light-emitting unit, a display unit and a light-guiding unit. The light guide has a light-emitting portion connects to a curved portion, wherein the light-emitting portion has at least two axial light-emitting planes to generate at least two axial light-emitting effects; the display unit has a first axial display layer corresponding to a first axial light-emitting plane, and a second axial display layer corresponding to a second axial light-emitting plane; the light-guiding unit is disposed on the light emitting portion, so as to enhance the light-emitting efficiency of the light-emitting portion; and, through the display unit and the light-guiding unit, the light-emitting and display effects of the multi-axial light-emitting plane on the light-emitting portion can be improved. Thereby, users may conveniently see the light-emitting display from different axial planes, in order to achieve the purposes of message prompt and indication.