Analyzing pre-processed code includes identifying at least one storage-modifying construct specifying a storage-modifying memory access to a memory hierarchy of a data processing system and determining if more than one granule of a cache line of data containing multiple granules that is targeted by the storage-modifying construct is subsequently referenced by said pre-processed code. Post-processed code including a storage-modifying instruction corresponding to the at least one storage-modifying construct in the pre-processed code is generated and stored. Generating the post-processed code includes marking the storage-modifying instruction with a partial cache line hint indicating that said storage-modifying instruction targets less than a full cache line of data within a memory hierarchy if the analyzing indicates only one granule of the target cache line will be accessed while the cache line is held in the cache memory and otherwise refraining from marking the storage-modifying instruction with the partial cache line hint.