A method and apparatus for hybrid automatic repeat request (HARQ) transmission are disclosed. If a packet has not been successfully transmitted, it is determined whether an HARQ early termination condition is met. If the HARQ early termination condition is met, the HARQ process is terminated and the packet is discarded at the HARQ level. The HARQ early termination condition is met if a positive acknowledgement (ACK) has not been received until the number of retransmissions reaches a predetermined limit that is dynamically configured based on channel condition, measurement, etc. Alternatively, the HARQ early termination condition is met if a transmit power required for successful transmission of the packet is much higher than an actual transmit power. Alternatively, the HARQ early termination condition is met if a transport format combination (TFC) selected for retransmission is different from an optimal TFC. A higher layer may be notified of the early HARQ termination.