发明授权
- 专利标题： Modulation of factor 11 expression
- 专利标题（中）： 调节因子11表达
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申请号： US12580241申请日： 2009-10-15
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公开(公告)号： US08334372B2公开(公告)日： 2012-12-18
- 发明人: Susan M. Freier , Brett P. Monia , Hong Zhang , Chenguang Zhao , Jeffrey R. Crosby , Andrew M. Siwkowski
- 申请人： Susan M. Freier , Brett P. Monia , Hong Zhang , Chenguang Zhao , Jeffrey R. Crosby , Andrew M. Siwkowski
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Isis Pharmaceuticals Patent Dept.
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/04
摘要：
Disclosed herein are antisense compounds and methods for decreasing Factor 11 and treating or preventing thromboembolic complications in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 11 include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, and stroke. Antisense compounds targeting Factor 11 can also be used as a prophylactic treatment to prevent individuals at risk for thrombosis and embolism.
公开/授权文献
- US20100137414A1 Modulation of Factor 11 Expression 公开/授权日：2010-06-03
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