发明授权
- 专利标题: Process for the preparation of intermediates useful in the synthesis of imatinib
- 专利标题(中): 制备可用于合成伊马替尼的中间体的方法
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申请号: US12784366申请日: 2010-05-20
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公开(公告)号: US08334381B2公开(公告)日: 2012-12-18
- 发明人: Alessandro Falchi , Ennio Grendele , Riccardo Motterle , Mariano Stivanello
- 申请人: Alessandro Falchi , Ennio Grendele , Riccardo Motterle , Mariano Stivanello
- 申请人地址: IT Montecchio Maggiore
- 专利权人: F.I.S. Fabbrica Italiana Sintetici S.p.A.
- 当前专利权人: F.I.S. Fabbrica Italiana Sintetici S.p.A.
- 当前专利权人地址: IT Montecchio Maggiore
- 代理机构: Dickstein Shapiro LLP
- 优先权: ITMI2006A2208 20061116; ITMI2007A0942 20070509
- 主分类号: C07D401/04
- IPC分类号: C07D401/04 ; C07D213/55
摘要:
It is the object of the present invention a process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.