Disclosed is a spacer grid assembly with mixing vanes supporting fuel rods of nuclear fuel assemblies and mixing coolant that flows around the fuel rods, and more particularly, a spacer grid equipped with mixing vanes that mix coolant flowing around fuel rods.The spacer grid with hydraulically balanced mixing vane patterns, in the spacer grid equipped with a strip dividing a plurality of unit grid cells and a plurality of springs, protruded in uniform directions of vertical and horizontal directions on a grid surface of the strip and supporting nuclear fuel rods, which includes: a plurality of mixing vanes protruded to the downstream of coolant on an upper end of the inner grid surface, wherein positions and directions of the mixing vanes are formed in regular patterns on the spacer grid. Thus, it can minimize coolant flow induced vibration of the spacer grid by balancing hydraulic load generated by the mixing vanes, around the center of the spacer grids.