A system for intelligent goal-directed search in large volume visual imagery using a cognitive-neural subsystem is disclosed. The system comprises an imager, a display, a display processor, a cognitive-neural subsystem, a system controller, and operator controls. The cognitive-neural subsystem comprises a cognitive module, a neural module, and an adaptation module. The cognitive module is configured to extract a set of regions of interest from the image using a cognitive algorithm. The neural module is configured to refine the set of regions of interest using a neural processing algorithm. The adaptation module is configured to bias the cognitive algorithm with information gained from the neural module to improve future searches. The system functions in a plurality of operating modes, including: batch mode, semi-interactive mode, real-time mode, and roaming mode.