发明授权
US08337864B2 Modified flagellin improved toll-like receptor 5 stimulating activity
有权
改良的鞭毛蛋白改善了toll样受体5刺激活性
- 专利标题： Modified flagellin improved toll-like receptor 5 stimulating activity
- 专利标题（中）： 改良的鞭毛蛋白改善了toll样受体5刺激活性
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申请号： US13333709申请日： 2011-12-21
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公开(公告)号： US08337864B2公开(公告)日： 2012-12-25
- 发明人: Joon Haeng Rhee , Shee Eun Lee , Soo Young Kim
- 申请人： Joon Haeng Rhee , Shee Eun Lee , Soo Young Kim
- 申请人地址： KR Gwangju
- 专利权人： Industry Foundation of Chonnam National University
- 当前专利权人： Industry Foundation of Chonnam National University
- 当前专利权人地址： KR Gwangju
- 代理机构： Sughrue Mion, PLLC
- 优先权： KR10-2007-0013846 20070209; KR10-2008-0011330 20080204
- 主分类号： A61K39/106
- IPC分类号： A61K39/106
摘要：
Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agonist flagellin so as to enhance the TRL-stimulating activity of the flagellin.