发明授权
- 专利标题： Indolin-2-ones and aza-indolin-2-ones
- 专利标题（中）： 二氢吲哚-2-酮和氮杂 - 二氢吲哚-2-酮
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申请号： US12663158申请日： 2008-06-20
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公开(公告)号： US08338422B2公开(公告)日： 2012-12-25
- 发明人: Gaston Stanislas Marcella Diels , Marc Gustaaf Celine Verdonck , Peter Jacobus Johannes Antonius Buijnsters , Kristof Van Emelen
- 申请人： Gaston Stanislas Marcella Diels , Marc Gustaaf Celine Verdonck , Peter Jacobus Johannes Antonius Buijnsters , Kristof Van Emelen
- 申请人地址： BE Beerse
- 专利权人： Janssen Pharmaceutica NV
- 当前专利权人： Janssen Pharmaceutica NV
- 当前专利权人地址： BE Beerse
- 优先权： EP07110764 20070621
- 国际申请： PCT/EP2008/057909 WO 20080620
- 国际公布： WO2008/155421 WO 20081224
- 主分类号： C07D209/34
- IPC分类号： C07D209/34 ; C07D471/04 ; C07D487/04 ; A61K31/404 ; A61K31/407 ; A61P35/00
摘要：
The present invention relates to compounds or pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to certain indolin-2-ones and aza-indolin-2-ones which possess anti-tumor activity and are accordingly useful in methods of treatment of the human or animal body, in particular such compounds are useful in the treatment of pathological processes which involve an aberrant cellular proliferation, such as tumor growth, rheumatoid arthritis, restenosis and atherosclerosis.
公开/授权文献
- US20100190786A1 INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES 公开/授权日：2010-07-29