Invention Grant
- Patent Title: Variants derived from ActRIIB and uses therefor
- Patent Title (中): 衍生自ActRIIB的变体并用于此
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Application No.: US12893976Application Date: 2010-09-29
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Publication No.: US08343933B2Publication Date: 2013-01-01
- Inventor: John Knopf , Jasbir Seehra , Ravindra Kumar
- Applicant: John Knopf , Jasbir Seehra , Ravindra Kumar
- Applicant Address: US MA Cambridge
- Assignee: Acceleron Pharma, Inc.
- Current Assignee: Acceleron Pharma, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Ropes & Gray LLP
- Main IPC: A61K38/16
- IPC: A61K38/16 ; C07K14/00 ; C07K14/705 ; C07K14/71
Abstract:
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.
Public/Granted literature
- US20110092670A1 VARIANTS DERIVED FROM ACTRIIB AND USES THEREFOR Public/Granted day:2011-04-21
Information query
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