Provided are an attitude control system and method of a spacecraft of an artificial satellite that may enhance a maneuverability and a controllability by simultaneously applying a reaction wheel and a thruster among drive units used to maneuver an attitude of the spacecraft of the artificial satellite. The attitude control system may include: a thruster-based attitude controller which control firing time of thrusters mounted on the spacecraft; and a reaction wheel-based attitude controller controlling driving of a reaction wheel mounted on the spacecraft. The spacecraft may include a plurality of reaction wheels. When a defect occurs in the spacecraft due to a partial malfunction of the reaction wheels, an attitude maneuverability of the spacecraft may be corrected by simultaneously applying the thruster-based attitude controller and the reaction wheel-based attitude controller.