A health monitoring system for a vehicle system includes a plurality of managers and a decision support module. Each manager corresponds to a different sub-system of the vehicle system, and generates manager output pertaining to the sub-system based at least in part on an intermediate output. Each manager comprises a plurality of reasoners. Each reasoner corresponds to a different component of the sub-system, and comprises a plurality of modules and a reasoner fusion block. Each module obtains data regarding a different aspect of the component and generates a preliminary output based on the data. The reasoner fusion block is coupled to the plurality of modules, receives the preliminary output, and generates the intermediate output based on the preliminary output. The decision support module is coupled to the plurality of managers, receives the manager output therefrom, and provides a decision support output based on the manager output.