A vehicle vacuum cleaning system may have a portable vacuum module that employs a vacuum module case, a vacuum fan within the interior of the vacuum module case and a vacuum fan drive shaft coupled to the vacuum fan. The vacuum module attaches and detaches to an HVAC module within the vehicle. The HVAC module may utilize an HVAC case, an electric motor within the HVAC case, an HVAC fan drive shaft coupled to the electric motor and an HVAC fan coupled to the HVAC fan drive shaft. The vacuum fan drive shaft is adapted to receive rotational energy from the HVAC fan drive shaft, either directly or through an auxiliary shaft. The vacuum module may employ gears to increase the speed and drawing force of the vacuum fan. A debris receptacle is detachable to the vacuum module. The HVAC fan drive shaft ultimately drives the vacuum fan.