A printhead subsystem is disclosed for selectively removing portions of a layer of dampening fluid disposed over an arbitrarily reimageable surface in a variable data lithographic system. The subsystem comprises a thermal printhead element disposed proximate the arbitrarily reimageable surface, and driving circuitry communicatively connected to the thermal printhead for selectively temporarily heating the thermal printhead to an elevated temperature. Portions of the dampening fluid layer proximate the thermal printhead are vaporized and driven off the arbitrarily reimageable surface by the thermal printhead when the thermal printhead is at the elevated temperature, to thereby form voids in the dampening fluid layer.