Pressure relief devices comprise a chamber having a piston disposed therein. One side of the piston defines a hydrostatic chamber in fluid communication with an outside environment, such as an isolated wellbore annulus, through a port. The other side of the piston defines a sealed or isolated chamber. The pressure relief device permits changes in pressure in the isolated wellbore annulus to be distributed into the chambers so as to either reduce the pressure within the isolated wellbore annulus or increase the pressure within the wellbore annulus, both of which lessen the likelihood that the change in pressure within the isolated wellbore annulus will damage wellbore components disposed therein.