A locking dispenser to dispense material from a replaceable refill container maintains a lock assembly having a plurality of spring-biased plungers configured in accordance with a predetermined lock parameter. The refill container carries a collar that includes a plurality of markers configured in accordance with a predetermined key parameter. Thus, when a refill container having a key parameter that is compatible with the lock parameter of the key block is installed at the dispenser, the plungers transition from a locked state to an unlocked state to enable the movement of an actuator, which when depressed by a user, results in the dispensement of material from the refill container.