Various forms of surgical instruments are disclosed. In various embodiments, the instrument includes a cartridge supporting assembly for operably supporting a staple cartridge therein. The cartridge supporting assembly may be responsive to firing and retraction motions applied thereto from a firing assembly. An anvil may be operably coupled to an anvil closure assembly. The anvil closure assembly may be constructed to selectively move the anvil in a proximal direction toward the cartridge supporting assembly to enable a portion of tissue to be clamped between a cartridge supported by the cartridge supporting assembly and the anvil under a predetermined amount of compression. The device may further include a closure actuator that operably interacts with the anvil closure assembly such that as the closure actuator is moved in a first direction, the anvil closure assembly causes the anvil to move in the proximal direction to increase the compression of the tissue between the staple cartridge and the anvil. A variable load generating member may cooperate with the anvil closure assembly and the closure actuator to apply a resistive load to the closure actuator in relation to an amount of compression applied to the tissue between the anvil and the staple cartridge.