A waterproof cable guide device for a railway vehicle comprises an elastic member having a plurality of through-holes penetrating in a forward and backward direction and screw insertion holes penetrating in the forward and backward direction, the plurality of electric cables being inserted into the plurality of holes, respectively, the elastic member being divided in positions of the through-holes or having slits extending from an outer peripheral surface of the elastic member to the through-holes, respectively; a press casing surrounding a front surface and an outer peripheral surface of the elastic member so as not to cover the through-holes and provided with screw insertion holes communicating with the screw insertion holes of the elastic member; and screws inserted into the screw insertion holes, in a direction from forward, and tightened with respect to the cable guide; the screws being inserted into the screw insertion holes in the direction from forward and tightened with respect to the cable guide in a state where the electric cables are inserted into the through-holes, respectively, to cause the elastic member to be compressed by the press casing to closely contact peripheral surfaces of the electric cables.