A vehicle body structure for fitting a pillar garnish and a fender panel is provided which surely prevents a space formed in the surface of a vehicle body from being viewed as black. The vehicle body structure includes a resin-made pillar garnish on a front surface side of a pillar of a vehicle body, a steel-made fender panel having an end on an end of the pillar garnish, and a seal member sealing a space between respective ends of the pillar garnish and the fender panel. The pillar garnish has an extending portion which extends in a direction from the end of the pillar garnish to the end of the fender panel. The fender panel has a flange which extends in a direction from the end of the fender panel to the end of the pillar garnish. The seal member is mounted on the extending portion and the flange.